1. Dendritic cells (DCs) are considered the most potent antigen-presenting cells (APCs). Upon capturing antigens, dendritic cells migrate to lymph nodes where they interact with T cells and B cells, providing a link between the innate and adaptive immune systems.
2. DCs have a unique morphology with long extensions called dendrites, which increase their surface area for capturing antigens.
3. DCs are located in tissues that are in contact with the external environment, such as the skin (Langerhans cells), mucosal linings of the nose, lungs, and intestines. They act as sentinels, constantly monitoring for pathogens.
4. Dendritic cells also play a role in inducing immune tolerance. They can present antigens in a way that promotes the development of regulatory T cells which help maintain immune homeostasis and prevent autoimmune reactions.
5. DC-based vaccines aim to enhance the immune response against cancers and chronic infections by loading DCs with specific antigens.
Image credit: Judith Behnsen, Priyanka Narang, Mike Hasenberg, Frank Gunzer, Ursula Bilitewski, Nina Klippel, Manfred Rohde, Matthias Brock, Axel A. Brakhage, Matthias Gunzer, CC BY 2.5 <https://lnkd.in/dWsEAwVh>, via Wikimedia Commons
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